We thus examined the associations of estradiol, estrone, and thirteen estrogen metabolites with breast cancer risk in prospectively saved urine samples from a populace-primarily based research of postmenopausal Women of all ages in Shanghai, China.
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), we didn't alter our Principal versions for BMI as a consequence of proof suggesting there isn't any Affiliation in between BMI and breast cancer impartial of estrogen (
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The concentrate on tissue particular wants are modified from the expression of various receptors and signaling pathways for the same steroid hormone, with more modulation of expression, or by the quantities or proportions of molecular species, permitting for even more modification in their effects beneath switching circumstances.
The function of estrogen metabolism in deciding breast cancer threat and differences in breast cancer fees among high-incidence and lower-incidence nations is poorly comprehended.
Antioxidants might help to neutralize no cost radical action, blocking the damaging effects of oxidative tension.
We also examined, on an exploratory foundation, how concentrations of estrogens/estrogen metabolites and estrogen metabolism profiles vary in between Shanghai and Asian American postmenopausal Females to determine whether variations could make clear higher breast cancer fees in the United States than in China.
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